Description
Reg. No. G4363 (Act 36/1947)
INDICATIONS
For the treatment and control of poultry red mite (Dermanyssus gallinae) and Northern fowl mite (Ornithonyssus sylviarum) infestation in pullets, breeders and layers.
COMPOSITION
Each 1 mℓ contains 10 mg fluralaner.
STORAGE INSTRUCTIONS
Store at or below 30 °C in a cool, dry place in the tightly closed, original container.
PHARMACOLOGICAL ACTION
Pharmacodynamic Properties
Fluralaner is an acaricide and an insecticide. It is efficacious against poultry mites, including Dermanyssus gallinae (poultry red mite) and Ornithonyssus sylviarum (Northern fowl mite). Fluralaner has a high potency against mites, mostly by exposure via feeding, i.e., it is systemically active on target parasites.
Fluralaner is a potent inhibitor of parts of the arthropod nervous system by acting antagonistically on ligand-gated chloride channels (GABA-receptor and glutamate receptor). In molecular on-target studies on insect GABA receptors of fleas and flies, fluralaner is not affected by dieldrin resistance.
The onset of efficacy against Dermanyssus gallinae is within 4 hours after exposure of the mites to treated chickens. All mites feeding on treated chickens are killed for at least 2 weeks after the first Exzolt® 10 mg/mℓ Oral Solution administration. Fluralaner stops the production of eggs by female mites.
The mite life cycle is broken due to the rapid onset of activity of fluralaner, the very high efficacy in killing mites feeding on treated chickens for a duration of at least 2 mite life cycles, and the absence of egg production from female mites exposed to treated chickens.
Exzolt® 10 mg/mℓ Oral Solution contributes toward the long-term control of the mite population in the poultry house. In clinical field studies, it was shown that treatment quickly eliminated Dermanyssus gallinae populations in treated houses and that parasite population regrowth was controlled when proper biosecurity measures were implemented.
In vitro bio-assays show that fluralaner is effective against parasites having proven field resistance including amidines (ticks), organophosphates (ticks, mites), cyclodienes (ticks, fleas, flies) macrocyclic lactones (sea lice), phenylpyrazoles (ticks, fleas) benzophenyl ureas (ticks), pyrethroids (ticks, mites) and carbamates (mites).
